- Abstract:
-
The synthesis of the epimeric 6-C-phenylglucoses is reported; these are the first compounds with one of the prochiral methylene hydrogens on C-6 of a hexose being replaced by an aryl group. Both isomers inhibit glucokinase and provide further indications that 6-C-alkyl- and 6-C-aryl-carbohydrates may provide a new range of sugar mimics that control enzymes associated with formation, hydrolysis and other fates of sugar-6-phosphates. X-ray crystal structures of 6-C-phenyl-L-glycero-β-D-gluco-he...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/0957-4166(96)00356-4
-
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- Journal:
- TETRAHEDRON-ASYMMETRY
- Volume:
- 7
- Issue:
- 9
- Pages:
- 2761-2772
- Publication date:
- 1996-09-05
- DOI:
- ISSN:
-
0957-4166
- URN:
-
uuid:4f536bea-5c03-4eba-9879-70e974570169
- Source identifiers:
-
45307
- Local pid:
- pubs:45307
- Language:
- English
- Copyright date:
- 1996
Journal article
The first example of a 6-C-aryl-D-glucose: Inhibition of glucokinase
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