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Hepatitis C virus: life cycle in cells, infection and host response, and analysis of molecular markers influencing the outcome of infection and response to therapy

Abstract:

Hepatitis C virus (HCV) is a major global health burden accounting for around 170 million chronic infections worldwide. Since its discovery, which dates back to about 30 years ago, many details of the viral genome organization and the astonishing genetic diversity have been unveiled but, owing to the difficulty of culturing HCV in vitro and obtaining fully susceptible yet immunocompetent in vivo models, we are still a long way from the full comprehension of viral life cycle, host cell pathway...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.cmi.2016.08.025

Authors


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Department:
Oxford, MSD, NDORMS, KIR
Bartolini, Barbara More by this author
Capobianchi, Maria R. More by this author
Pistello, Mauro More by this author
Publisher:
Elsevier Publisher's website
Journal:
Clinical microbiology and infection Journal website
Volume:
22
Issue:
10
Pages:
826-832
Publication date:
2016-08-31
Acceptance date:
2016-08-25
DOI:
EISSN:
1469-0691
ISSN:
1198-743X
Pubs id:
pubs:641873
URN:
uri:4f446995-19bb-4e35-9ddc-05895dba001c
UUID:
uuid:4f446995-19bb-4e35-9ddc-05895dba001c
Local pid:
pubs:641873

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