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Gene-age interactions in blood pressure regulation: A large-scale investigation with the CHARGE, global BPgen, and ICBP consortia

Abstract:

Although age-dependent effects on blood pressure (BP) have been reported, they have not been systematically investigated in large-scale genome-wide association studies (GWASs). We leveraged the infrastructure of three well-established consortia (CHARGE, GBPgen, and ICBP) and a nonstandard approach (age stratification and metaregression) to conduct a genome-wide search of common variants with age-dependent effects on systolic (SBP), diastolic (DBP), mean arterial (MAP), and pulse (PP) pressure...

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Publisher copy:
10.1016/j.ajhg.2014.05.010

Authors


Chasman, DI More by this author
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Publisher:
Cell Press
Journal:
American Journal of Human Genetics
Volume:
95
Issue:
1
Pages:
24-38
Publication date:
2014-07-03
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:4f4335ea-d5f9-4c38-a2fe-d7de7a8a4937
Source identifiers:
476634
Local pid:
pubs:476634
Language:
English

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