- Abstract:
-
Dectin-1 is a pathogen-recognition receptor on macrophages (MPhis), neutrophils, and dendritic cells (DCs). On MPhis and bone marrow-derived DCs, it has been shown to mediate the nonopsonic recognition of and response to soluble and particulate yeast beta-glucans. We have optimized the immunohistochemical detection of Dectin-1 and demonstrated its expression on neutrophils, subpopulations of MPhis in splenic red and white pulp, alveolar MPhis, Kupffer cells, and MPhis and DCs in the lamina pr...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1189/jlb.0104031
-
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- Volume:
- 76
- Issue:
- 1
- Pages:
- 86-94
- Publication date:
- 2004-07-05
- DOI:
- EISSN:
-
1938-3673
- ISSN:
-
0741-5400
- URN:
-
uuid:4f370c09-c19d-421b-9c9a-38a5261e8f62
- Source identifiers:
-
25733
- Local pid:
- pubs:25733
- Copyright date:
- 2004
Conference
Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions.
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