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Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions.

Abstract:

Dectin-1 is a pathogen-recognition receptor on macrophages (MPhis), neutrophils, and dendritic cells (DCs). On MPhis and bone marrow-derived DCs, it has been shown to mediate the nonopsonic recognition of and response to soluble and particulate yeast beta-glucans. We have optimized the immunohistochemical detection of Dectin-1 and demonstrated its expression on neutrophils, subpopulations of MPhis in splenic red and white pulp, alveolar MPhis, Kupffer cells, and MPhis and DCs in the lamina pr...

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Publication status:
Published

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Publisher copy:
10.1189/jlb.0104031

Authors


Montoya, M More by this author
Taylor, PR More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Volume:
76
Issue:
1
Pages:
86-94
Publication date:
2004-07-05
DOI:
EISSN:
1938-3673
ISSN:
0741-5400
URN:
uuid:4f370c09-c19d-421b-9c9a-38a5261e8f62
Source identifiers:
25733
Local pid:
pubs:25733

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