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The deleted in colorectal carcinoma (DCC) gene 201 R --> G polymorphism: no evidence for genetic association with autoimmune disease.

Abstract:

The product of the deleted in colorectal carcinoma (DCC) gene has a role in apoptosis and is a positional candidate for IDDM6, the putative chromosome 18q12-q23 autoimmune disease locus. We hypothesised that a nonconservative substitution (DCC 201 R --> G; nucleotide (nt) 601 C --> G), located in an extracellular immunoglobulin-like domain of DCC, is an aetiological determinant of autoimmunity. We tested this hypothesis by genetically testing the nt 601 C --> G polymorphism for assoc...

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Publisher copy:
10.1038/sj.ejhg.5201059

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Journal:
European journal of human genetics : EJHG
Volume:
11
Issue:
11
Pages:
840-844
Publication date:
2003-11-05
DOI:
EISSN:
1476-5438
ISSN:
1018-4813
URN:
uuid:4f2aca42-6c99-45ea-87de-72d733900833
Source identifiers:
176353
Local pid:
pubs:176353

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