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Liver fat accumulation is associated with reduced hepatic insulin extraction and beta cell dysfunction in healthy older individuals.

Abstract:

BACKGROUND: There is a well-established association between type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) secondary to excess accumulation of intrahepatic lipid (IHL), but the mechanistic basis for this association is unclear. Emerging evidence suggests that in addition to being associated with insulin resistance, NAFLD may be associated with relative beta-cell dysfunction. We sought to determine the influence of liver fat on hepatic insulin extraction and indices of beta-cell...

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Publication status:
Published

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Publisher copy:
10.1186/1758-5996-6-43

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Publisher:
BioMed Central Ltd.
Journal:
Diabetology and metabolic syndrome
Volume:
6
Issue:
1
Pages:
43
Publication date:
2014-01-01
DOI:
EISSN:
1758-5996
ISSN:
1758-5996
URN:
uuid:4f265dfc-28a1-468e-8c43-d8a87aaae020
Source identifiers:
464863
Local pid:
pubs:464863

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