Journal article icon

Journal article

Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection.

Abstract:

A B lymphocyte hyperactivity syndrome resembling systemic lupus erythematosus characterizes mice lacking the src-family kinase Lyn. Lyn is not required to initiate B cell antigen receptor (BCR) signaling but is an essential inhibitory component. lyn-/- B cells have a delayed but increased calcium flux and exaggerated negative selection responses in the presence of antigen and spontaneous hyperactivity in the absence of antigen. As in invertebrates, genetic effects of loci with only one functi...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Molecular Medicine
Role:
Author
Expand authors...
Journal:
Immunity
Volume:
8
Issue:
4
Pages:
497-508
Publication date:
1998-04-05
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
URN:
uuid:4f22797e-572b-47c5-8c32-91fed7d87d32
Source identifiers:
29145
Local pid:
pubs:29145

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP