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Efficient differentiation of human induced pluripotent stem cells generates cardiac cells that provide protection following myocardial infarction in the rat.

Abstract:

Induced pluripotent stem (iPS) cells are being used increasingly to complement their embryonic counterparts to understand and develop the therapeutic potential of pluripotent cells. Our objectives were to identify an efficient cardiac differentiation protocol for human iPS cells as monolayers, and demonstrate that the resulting cardiac progenitors could provide a therapeutic benefit in a rodent model of myocardial infarction. Herein, we describe a 14-day protocol for efficient cardiac differe...

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Publication status:
Published

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Publisher copy:
10.1089/scd.2011.0075

Authors


Carpenter, L More by this author
Stuckey, DJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
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Journal:
Stem cells and development
Volume:
21
Issue:
6
Pages:
977-986
Publication date:
2012-04-05
DOI:
EISSN:
1557-8534
ISSN:
1547-3287
URN:
uuid:4f1a8954-a148-487e-9261-13ef084628d7
Source identifiers:
313169
Local pid:
pubs:313169

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