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Journal article

Deactivation of vascular endothelium by monoclonal anti-tumor necrosis factor alpha antibody in rheumatoid arthritis.

Abstract:

OBJECTIVE: To assess whether monoclonal antibody to tumor necrosis factor alpha (TNF alpha) reduces endothelial activation in rheumatoid arthritis (RA). METHODS: Levels of serum E-selectin, intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1), and circulating leukocytes (differential counts) were measured in RA patients before and up to 4 weeks after infusion of either placebo or chimeric anti-TNF alpha antibody cA2 (1 or 10 mg/kg). RESULTS: Treatment wit...

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Publication status:
Published

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Publisher copy:
10.1002/art.1780390703

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Arthritis and rheumatism
Volume:
39
Issue:
7
Pages:
1082-1091
Publication date:
1996-07-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:4f19ee08-4516-4f32-bfdb-2f31127ccd5e
Source identifiers:
481622
Local pid:
pubs:481622

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