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Effect of a selective 5-hydroxytryptamine reuptake inhibitor on brain extracellular noradrenaline: microdialysis studies using paroxetine.

Abstract:

The clinical efficacy of selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors (SSRIs) is normally attributed to their ability to increase brain 5-HT function although recent preclinical findings indicate that their selectivity for 5-HT over noradrenaline may be less evident in vivo. The present study investigated the effects of the SSRI, paroxetine, on extracellular levels of noradrenaline. Microdialysis was carried out in the hippocampus of the awake rat. In rats treated twice...

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Publication status:
Published

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Authors


Hajós-Korcsok, E More by this author
McTavish, SF More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
European journal of pharmacology
Volume:
407
Issue:
1-2
Pages:
101-107
Publication date:
2000-10-05
DOI:
EISSN:
1879-0712
ISSN:
0014-2999
URN:
uuid:4f19d3ad-1c1b-4f38-b8dc-14b02c2e0506
Source identifiers:
185181
Local pid:
pubs:185181

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