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Journal article

Immunoglobulin M and D antigen receptors are both capable of mediating B lymphocyte activation, deletion, or anergy after interaction with specific antigen.

Abstract:

A series of immunoglobulin (Ig)-transgenic mice were generated to study the functional capabilities of the IgM and IgD classes of B lymphocyte antigen receptor in regulating both cellular development and responses to specific antigen. B cells from Ig-transgenic mice expressing either hen-egg lysozyme (HEL)-specific IgM or IgD alone were compared with B cells from mice that coexpressed IgM and IgD of the same anti-HEL specificity. In all three types of Ig-transgenic mice, conventional B cells ...

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Publication status:
Published

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Publisher copy:
10.1084/jem.176.4.991

Authors


Goodnow, CC More by this author
Crosbie, J More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
The Journal of experimental medicine
Volume:
176
Issue:
4
Pages:
991-1005
Publication date:
1992-10-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:4f09de39-71c0-46a5-b472-885f5aaf5eeb
Source identifiers:
55571
Local pid:
pubs:55571

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