Journal article icon

Journal article

Slow recovery of excitability increases ventricular fibrillation risk as identified by emulation

Abstract:
Purpose: Rotor stability and meandering are key mechanisms determining and sustaining cardiac fibrillation, with important implications for anti-arrhythmic drug development. However, little is yet known on how rotor dynamics are modulated by variability in cellular electrophysiology, particularly on kinetic properties of ion channel recovery. Methods: We propose a novel emulation approach, based on Gaussian process regression augmented with machine learning, ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.3389/fphys.2018.01114

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Computer Science
Role:
Author
More from this funder
Funding agency for:
Bueno Orovio, A
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Physiology Journal website
Volume:
9
Pages:
Article: 1114
Publication date:
2018-08-28
Acceptance date:
2018-07-25
DOI:
ISSN:
1664-042X
Pubs id:
pubs:891101
URN:
uri:4f07b19f-f506-4355-8f44-75213f9e7d14
UUID:
uuid:4f07b19f-f506-4355-8f44-75213f9e7d14
Local pid:
pubs:891101

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP