- Abstract:
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Purpose: Rotor stability and meandering are key mechanisms determining and sustaining cardiac fibrillation, with important implications for anti-arrhythmic drug development. However, little is yet known on how rotor dynamics are modulated by variability in cellular electrophysiology, particularly on kinetic properties of ion channel recovery. Methods: We propose a novel emulation approach, based on Gaussian process regression augmented with machine learning, ... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 3.7MB)
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- Publisher copy:
- 10.3389/fphys.2018.01114
-
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- Funding agency for:
- Bueno Orovio, A
- Funding agency for:
- Bueno Orovio, A
- Publisher:
- Frontiers Media Publisher's website
- Journal:
- Frontiers in Physiology Journal website
- Volume:
- 9
- Pages:
- Article: 1114
- Publication date:
- 2018-08-28
- Acceptance date:
- 2018-07-25
- DOI:
- ISSN:
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1664-042X
- Pubs id:
-
pubs:891101
- URN:
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uri:4f07b19f-f506-4355-8f44-75213f9e7d14
- UUID:
-
uuid:4f07b19f-f506-4355-8f44-75213f9e7d14
- Local pid:
- pubs:891101
- Copyright holder:
- Lawson et al.
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Lawson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Journal article
Slow recovery of excitability increases ventricular fibrillation risk as identified by emulation
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+ National Centre for the Replacement, Refinement and Reduction of Animals in Research
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