Journal article
Slow recovery of excitability increases ventricular fibrillation risk as identified by emulation
- Abstract:
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Purpose: Rotor stability and meandering are key mechanisms determining and sustaining cardiac fibrillation, with important implications for anti-arrhythmic drug development. However, little is yet known on how rotor dynamics are modulated by variability in cellular electrophysiology, particularly on kinetic properties of ion channel recovery. Methods: We propose a novel emulation approach, based on Gaussian process regression augmented with machine learning, ... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
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- Files:
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(Version of record, pdf, 3.7MB)
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- Publisher copy:
- 10.3389/fphys.2018.01114
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Authors
Funding
+ British Heart Foundation
More from this funder
Funding agency for:
Bueno Orovio, A
Grant:
RE/13/1/30181
+ National Centre for the Replacement, Refinement and Reduction of Animals in Research
More from this funder
Funding agency for:
Bueno Orovio, A
Grant:
RE/13/1/30181
+ Oxford BHF Centre of Research Excellence
More from this funder
Funding agency for:
Bueno Orovio, A
Grant:
RE/13/1/30181
Bibliographic Details
- Publisher:
- Frontiers Media Publisher's website
- Journal:
- Frontiers in Physiology Journal website
- Volume:
- 9
- Article number:
- 1114
- Publication date:
- 2018-08-28
- Acceptance date:
- 2018-07-25
- DOI:
- ISSN:
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1664-042X
- Source identifiers:
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891101
Item Description
- Keywords:
- Pubs id:
-
pubs:891101
- UUID:
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uuid:4f07b19f-f506-4355-8f44-75213f9e7d14
- Local pid:
- pubs:891101
- Deposit date:
- 2018-07-25
Terms of use
- Copyright holder:
- Lawson et al
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Lawson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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