- Abstract:
-
Cytochrome P450 (CYP) enzymes are involved in activating the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs) in mammals, but they are also utilized by microorganisms for the degradation of these hazardous environmental contaminants. Wild-type CYP102 (P450(BM-3)) from Bacillus megaterium has low activity for the oxidation of the PAHs phenanthrene, fluoranthene and pyrene. The double hydrophobic substitution R47L/Y51F at the entrance of the substrate access channel increased the PAH ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1046/j.1432-1327.2001.02212.x
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- Journal:
- European journal of biochemistry / FEBS
- Volume:
- 268
- Issue:
- 10
- Pages:
- 3117-3125
- Publication date:
- 2001-05-05
- DOI:
- EISSN:
-
1432-1033
- ISSN:
-
0014-2956
- URN:
-
uuid:4eff954b-10bd-407d-94b2-698a402d9330
- Source identifiers:
-
31880
- Local pid:
- pubs:31880
- Language:
- English
- Keywords:
- Copyright date:
- 2001
Journal article
Protein engineering of Bacillus megaterium CYP102. The oxidation of polycyclic aromatic hydrocarbons.
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