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Journal article

UnPAKing the class differences among p21-activated kinases.

Abstract:

The p21-activated kinases (PAKs) are signal transducers, central to many vital cellular processes, including cell morphology, motility, survival, gene transcription and hormone signalling. The mammalian PAK family contains six serine/threonine kinases divided into two subgroups, group I (PAK 1-3) and group II (PAK4-6), based on their domain architecture and regulation. PAKs functioning as dynamic signalling nodes present themselves as attractive therapeutic targets in tumours, neurological di...

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Publication status:
Published

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Publisher copy:
10.1016/j.tibs.2008.06.002

Authors


Eswaran, J More by this author
Soundararajan, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Journal:
Trends in biochemical sciences
Volume:
33
Issue:
8
Pages:
394-403
Publication date:
2008-08-05
DOI:
ISSN:
0968-0004
URN:
uuid:4ef43529-0f36-4517-9cf8-cf5ba50b8d6b
Source identifiers:
34320
Local pid:
pubs:34320

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