UnPAKing the class differences among p21-activated kinases.

Journal article

The p21-activated kinases (PAKs) are signal transducers, central to many vital cellular processes, including cell morphology, motility, survival, gene transcription and hormone signalling. The mammalian PAK family contains six serine/threonine kinases divided into two subgroups, group I (PAK 1-3) and group II (PAK4-6), based on their domain architecture and regulation. PAKs functioning as dynamic signalling nodes present themselves as attractive therapeutic targets in tumours, neurological di...

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Authors: Eswaran, J; Soundararajan, M; Kumar, R; Knapp, S

• Publication status: Published
• Journal: Trends in biochemical sciences
• Volume: 33
• Issue: 8
• Pages: 394-403
• Publication date: 2008-08-01
• DOI: 10.1016/j.tibs.2008.06.002
• ISSN: 0968-0004
• Language: English
• Keywords: Substrate Specificity; Catalysis; p21-Activated Kinases; Signal Transduction