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Repression of DNA replication licensing in quiescence is independent of geminin and may define the cell cycle state of progenitor cells.

Abstract:

The DNA replication (or origin) licensing machinery ensures precise duplication of the genome and contributes to the regulation of proliferative capacity in metazoa. Using an in vitro fibroblast model system coupled to a cell-free DNA replication assay, we have studied regulation of the origin licensing pathway during exit from and re-entry into the mitotic cell cycle. We show that in the quiescent state (G0) loss of proliferative capacity is achieved in part through down-regulation of the re...

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Publisher copy:
10.1016/j.yexcr.2005.05.027

Authors


Kingsbury, SR More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences
Obermann, EC More by this author
Prevost, AT More by this author
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Journal:
Experimental cell research
Volume:
309
Issue:
1
Pages:
56-67
Publication date:
2005-09-05
DOI:
EISSN:
1090-2422
ISSN:
0014-4827
URN:
uuid:4eebf504-1cc6-4b29-a478-1afeba46fb1c
Source identifiers:
387994
Local pid:
pubs:387994

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