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Chemokines and TRANCE as genetic adjuvants for a DNA vaccine to rabies virus

Abstract:

An adaptive immune response is initiated by mature dendritic cells presenting processed antigen to naïve T cells. Assuming that the magnitude of the immune response is influenced by the number and type of antigen-presenting dendritic cells and by the duration of antigen presentation, we tested if chemokines that bind to receptors expressed on immature dendritic cells or TRANCE, a survival factor for mature dendritic cells, can serve as adjuvants. None of the immunomodulaters given as genetic ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Journal:
Cellular Immunology
Volume:
224
Issue:
2
Pages:
105-112
Publication date:
2003-08-05
DOI:
ISSN:
0008-8749
URN:
uuid:4eebc436-e71a-4d39-bf3f-7e07d1b57b83
Source identifiers:
279145
Local pid:
pubs:279145
Language:
English

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