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Journal article

Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen.

Abstract:

A transgenic mouse was generated expressing on most (> 80%) of thymocytes and peripheral T cells a T-cell receptor isolated from a cytotoxic T-cell clone (F5). This clone is CD8+ and recognizes alpha alpha 366-374 of the nucleoprotein (NP 366-374) of influenza virus (A/NT/60/68), in the context of Class I MHC Db (Townsend et al., 1986). The receptor utilizes the V beta 11 and V alpha 4 gene segments for the beta chain and alpha chain, respectively (Palmer et al., 1989). The usage of V beta...

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Publication status:
Published

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Publisher copy:
10.1155/1993/98015

Authors


Mamalaki, C More by this author
Elliott, J More by this author
Yannoutsos, N More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
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Journal:
Developmental immunology
Volume:
3
Issue:
3
Pages:
159-174
Publication date:
1993-01-05
DOI:
ISSN:
1044-6672
URN:
uuid:4ed03d9f-c609-4238-b8a1-99f7493b87be
Source identifiers:
11924
Local pid:
pubs:11924

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