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A triply divergent reagent for glycoprotein synthesis

Abstract:
Chemical synthesis of glycoproteins through three different strategies, from the same reagent, is herein described. The flexibility of this system, which allows the comparison of different linkage motifs between the same glycan and protein, is shown by one-step diversification of a GlcNAc-ylating reagent and its application in both site-specific and non-site-specific glycoprotein synthesis to create different conjugates from common representative protein scaffolds.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/ijch.201400182

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Publisher:
Wiley Online Library Publisher's website
Journal:
Israel Journal of Chemistry Journal website
Volume:
55
Issue:
3-4
Pages:
387-391
Publication date:
2015-03-03
Acceptance date:
2014-12-16
DOI:
EISSN:
1869-5868
ISSN:
0021-2148
URN:
uuid:4ec74b00-a76d-4b2e-9740-511c4d2b37e3
Source identifiers:
519644
Local pid:
pubs:519644
Paper number:
3-4
Keywords:

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