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Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle.

Abstract:

A cDNA clone encoding an inwardly-rectifying potassium channel subunit (Kir6.2) was isolated from an insulinoma cDNA library. The mRNA is strongly expressed in brain, skeletal muscle, cardiac muscle and in insulinoma cells, weakly expressed in lung and kidney and not detectable in spleen, liver or testis. Heterologous expression of Kir6.2 in HEK293 cells was only observed when the cDNA was cotransfected with that of the sulphonylurea receptor (SUR). Whole-cell Kir6.2/SUR currents were K+...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher version

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Publisher copy:
10.1016/0014-5793(95)01369-5

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
British Diabetic Association More from this funder
Wellcome Trust More from this funder
Publisher:
Elsevier B.V. Publisher's website
Journal:
FEBS letters Journal website
Volume:
377
Issue:
3
Pages:
338-344
Publication date:
1995-12-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:4ec1303a-c463-4514-b616-80911008040d
Source identifiers:
113666
Local pid:
pubs:113666

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