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Combating multidrug-resistant Plasmodium falciparum malaria.

Abstract:

Over the past 50 years, Plasmodium falciparum has developed resistance against all antimalarial drugs used against it: chloroquine, sulphadoxine-pyrimethamine, quinine, piperaquine and mefloquine. More recently, resistance to the artemisinin derivatives and the resulting failure of artemisinin-based combination therapy (ACT) are threatening all major gains made in malaria control. Each time resistance has developed progressively, with delayed clearance of parasites first emerging only in a fe...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1111/febs.14127

Authors


More by this author
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Landier, J More by this author
Parker, DM More by this author
More by this author
Department:
Oxford, MSD, NDM, Tropical Medicine
Wellcome Trust More from this funder
Publisher:
Wiley Publisher's website
Journal:
FEBS Journal Journal website
Volume:
284
Issue:
16
Pages:
2569-2578
Publication date:
2017-06-05
Acceptance date:
2017-06-01
DOI:
EISSN:
1742-4658
ISSN:
1742-464X
Pubs id:
pubs:700596
URN:
uri:4ebd8bba-21c6-4818-889f-fce2d565cfc3
UUID:
uuid:4ebd8bba-21c6-4818-889f-fce2d565cfc3
Local pid:
pubs:700596

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