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Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Abstract:

Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 × 10...

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Publisher copy:
10.1038/ng.2652

Authors


Berndt, SI More by this author
Skibola, CF More by this author
Nieters, A More by this author
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Journal:
Nature Genetics
Volume:
45
Issue:
8
Pages:
868-876
Publication date:
2013-08-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:4eb92b71-6f3b-4f5a-9e44-6057e14aadeb
Source identifiers:
416909
Local pid:
pubs:416909
Language:
English

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