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Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor.

Abstract:

1. ATP-sensitive potassium (KATP) channels are composed of pore-forming Kir6.2 and regulatory SUR subunits. ATP inhibits the channel by interacting with Kir6.2, while sulphonylureas block channel activity by interaction with a high-affinity site on SUR1 and a low-affinity site on Kir6.2. MgADP and diazoxide interact with SUR1 to promote channel activity. 2. We examined the effect of N-terminal deletions of Kir6.2 on the channel open probability, ATP sensitivity and sulphonylurea sensitivity b...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Condensed Matter Physics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
The Journal of physiology
Volume:
518 ( Pt 2)
Issue:
2
Pages:
325-336
Publication date:
1999-07-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:4eaf1aef-0d67-4922-af61-26ab200803f9
Source identifiers:
21572
Local pid:
pubs:21572

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