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Journal article

In vitro and in vivo evaluations of a hydrophilic 64Cu-bis(thiosemicarbazonato)-glucose conjugate for hypoxia imaging.

Abstract:

UNLABELLED: A water-soluble glucose conjugate of the hypoxia tracer 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) (64Cu-ATSM) was synthesized and radiolabeled (64Cu-ATSE/A-G). Here we report our initial biological experiments with 64Cu-ATSE/A-G and compare the results with those obtained for 64Cu-ATSM and 18F-FDG. METHODS: The uptake of 64Cu-ATSE/A-G and 64Cu-ATSM into HeLa cells in vitro was investigated at a range of dissolved oxygen concentrations representing normoxia, hypoxia, and anoxia...

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Publication status:
Published

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Publisher copy:
10.2967/jnumed.108.054015

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Journal:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume:
49
Issue:
11
Pages:
1862-1868
Publication date:
2008-11-05
DOI:
EISSN:
1535-5667
ISSN:
0161-5505
URN:
uuid:4eac85ca-95f2-4d7a-ab17-887f441331f5
Source identifiers:
34427
Local pid:
pubs:34427

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