Clinical studies of the effectiveness and safety of antivenoms

Journal article

In the 1890s, hyperimmune sera proved effective in animals against challenge by the snake venom against which they had been raised. They were first used, apparently successfully, in a human patient in about 1895. Since then, antivenoms have become accepted as the only reliable specific treatment for snake-bite envenoming. Despite decades of accumulated clinical experience and a number of published randomized comparative and observational studies, the clinical effectiveness and safety of some ...

Expand abstract

Authors: Williams, D; Habib, A; Warrell, D

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Toxicon
• Volume: 150
• Pages: 1-10
• Publication date: 2018-05-07
• Acceptance date: 2018-05-02
• DOI: 10.1016/j.toxicon.2018.05.001
• EISSN: 1879-3150
• ISSN: 0041-0101
• Pmid: 29746978
• Language: English
• Keywords: adverse reactions; pre-clinical testing; placebo control; blinding; ethical considerations; clinical trials; post-marketing surveillance; antivenom; randomized controlled trials