Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis.

Journal article

CONTEXT: Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population. OBJECTIVE: To generate large-scale evidence on whether 2 common variants of LRP5 (Val667Met, Ala1330Val) and 1 variant of LRP6 (Ile1062Val) are associated with BMD and fracture risk. DESIGN AND SETTING: Prospective, multicenter, collaborative study of ...

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Authors: van Meurs, J; Trikalinos, T; Ralston, S; Balcells, S; Brandi, M

• Publication status: Published
• Journal: JAMA
• Volume: 299
• Issue: 11
• Pages: 1277-1290
• Publication date: 2008-03-01
• DOI: 10.1001/jama.299.11.1277
• EISSN: 1538-3598
• ISSN: 0098-7484
• Language: English
• Keywords: Fractures, Bone; Humans; Phenotype; Low Density Lipoprotein Receptor-Related Protein-6; Prospective Studies; Risk Factors; GENOMOS Study; Spinal Fractures; Femur Neck; LDL-Receptor Related Proteins; Bone Density; Polymorphism, Single Nucleotide; Lumbar Vertebrae; Genotype; Osteoporosis; Low Density Lipoprotein Receptor-Related Protein-5