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Journal article

Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis.

Abstract:

CONTEXT: Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population. OBJECTIVE: To generate large-scale evidence on whether 2 common variants of LRP5 (Val667Met, Ala1330Val) and 1 variant of LRP6 (Ile1062Val) are associated with BMD and fracture risk. DESIGN AND SETTING: Prospective, multicenter, collaborative study of ...

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Publication status:
Published

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Publisher copy:
10.1001/jama.299.11.1277

Authors


van Meurs, JB More by this author
Trikalinos, TA More by this author
Ralston, SH More by this author
Balcells, S More by this author
Brandi, ML More by this author
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Journal:
JAMA
Volume:
299
Issue:
11
Pages:
1277-1290
Publication date:
2008-03-05
DOI:
EISSN:
1538-3598
ISSN:
0098-7484
URN:
uuid:4e8d657b-c457-454c-9b8b-3f5a9c9abd10
Source identifiers:
473782
Local pid:
pubs:473782

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