- Abstract:
-
CONTEXT: Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population. OBJECTIVE: To generate large-scale evidence on whether 2 common variants of LRP5 (Val667Met, Ala1330Val) and 1 variant of LRP6 (Ile1062Val) are associated with BMD and fracture risk. DESIGN AND SETTING: Prospective, multicenter, collaborative study of ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1001/jama.299.11.1277
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- Journal:
- JAMA
- Volume:
- 299
- Issue:
- 11
- Pages:
- 1277-1290
- Publication date:
- 2008-03-05
- DOI:
- EISSN:
-
1538-3598
- ISSN:
-
0098-7484
- URN:
-
uuid:4e8d657b-c457-454c-9b8b-3f5a9c9abd10
- Source identifiers:
-
473782
- Local pid:
- pubs:473782
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis.
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