Assessing prognosis from nonrandomized studies: an example from brain arteriovenous malformations.

Journal article

Two recent publications from Helsinki and Toronto that investigated the natural history of brain AVMs are the background topic for reviewing some principles and pitfalls of prognostic studies. Multivariable prognostic research involves 3 steps: developing the prognostic model, validating its performance in other individuals, and assessing its clinical impact on patients' outcomes. Unfortunately, the predictive ability of the model can be poor when it is applied to a new population, and clinic...

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Authors: Raymond, J; Naggara, O; Guilbert, F; Altman, D

• Publication status: Published
• Journal: AJNR. American journal of neuroradiology
• Volume: 32
• Issue: 5
• Pages: 809-812
• Publication date: 2011-05-01
• DOI: 10.3174/ajnr.a2516
• EISSN: 1936-959X
• ISSN: 0195-6108
• Language: English
• Keywords: Risk Factors; Outcome Assessment (Health Care); United States; Survival Rate; Survival Analysis; Prognosis; Clinical Trials as Topic; Risk Assessment; Humans; Intracranial Arteriovenous Malformations; Prevalence