High-throughput sequencing allows detailed study of the BCR repertoire postimmunization, but it remains unclear to what extent the de novo identification of Ag-specific sequences from the total BCR repertoire is possible. A conjugate vaccine containing Haemophilus influenzae type b (Hib) and group C meningococcal polysaccharides, as well as tetanus toxoid (TT), was used to investigate the BCR repertoire of adult humans following immunization and to test the hypothesis that public or convergen...Expand abstract
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- Peer reviewed
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- Trück, J
- American Association of Immunologists Publisher's website
- Journal of immunology (Baltimore, Md. : 1950) Journal website
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- American Association of Immunologists, Inc.
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- Copyright © 2014 by The American Association of Immunologists, Inc.
Identification of antigen-specific B cell receptor sequences using public repertoire analysis.
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