Journal article
A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.
- Abstract:
-
BACKGROUND: ATP-sensitive potassium (KATP) channels are major regulators of glucose-induced insulin secretion in pancreatic beta cells. We have described a dominant heterozygous mutation--E1506K--in the sulfonylurea receptor 1 (SUR1) gene (ABCC8) in a Finnish family, which leads to congenital hyperinsulinaemia due to reduction of K(ATP)-channel activity. We aimed to characterise glucose metabolism in adults heterozygous for the E1506K mutation. METHODS: Glucose tolerance was assessed by an o...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/s0140-6736(03)12325-2
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Bibliographic Details
- Journal:
- Lancet
- Volume:
- 361
- Issue:
- 9354
- Pages:
- 301-307
- Publication date:
- 2003-01-01
- DOI:
- EISSN:
-
1474-547X
- ISSN:
-
0140-6736
- Source identifiers:
-
114596
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:114596
- UUID:
-
uuid:4e81d0c3-6ccf-4723-bc5d-37824409615b
- Local pid:
- pubs:114596
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2003
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