A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.

Huopio, H; Otonkoski, T; Vauhkonen, I; Reimann, F; Ashcroft, FM; Laakso, M

Abstract:

BACKGROUND: ATP-sensitive potassium (KATP) channels are major regulators of glucose-induced insulin secretion in pancreatic beta cells. We have described a dominant heterozygous mutation--E1506K--in the sulfonylurea receptor 1 (SUR1) gene (ABCC8) in a Finnish family, which leads to congenital hyperinsulinaemia due to reduction of K(ATP)-channel activity. We aimed to characterise glucose metabolism in adults heterozygous for the E1506K mutation. METHODS: Glucose tolerance was assessed by an o...

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APA Style

Huopio, H., Otonkoski, T., Vauhkonen, I., Reimann, F., Ashcroft, F. M., & Laakso, M. (2003). A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1. Lancet, 361(9354), 301–307.

MLA Style

Huopio, H., et al. “A New Subtype of Autosomal Dominant Diabetes Attributable to a Mutation in the Gene for Sulfonylurea Receptor 1.” Lancet, vol. 361, no. 9354, Lancet, 2003, pp. 301–07.

Chicago Style

Huopio, H, T Otonkoski, I Vauhkonen, F Reimann, FM Ashcroft, and M Laakso. 2003. “A New Subtype of Autosomal Dominant Diabetes Attributable to a Mutation in the Gene for Sulfonylurea Receptor 1.” Lancet 361 (9354): 301–7.
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