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DNA duplexes stabilized by modified monomer residues: synthesis and stability

Abstract:

The synthesis of a series of 2′-deoxyuridine analogues modified at the 5-position and a series of 2′-deoxypurines modified at the 8-position is described. Ultraviolet melting studies have been used to assess the stability of DNA duplexes 12- and 8-residues in length that contain these modifications. Of those modified residues which have been incorporated into oligonucleotides, 5-(prop-1-ynyl)-2′-deoxyuridine is found to impart the greatest increase in stability on the DNA duplexes studied. Th...

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Publication status:
Published

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Publisher copy:
10.1039/a707031d

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
Issue:
6
Pages:
1131-1138
Publication date:
1998-03-21
DOI:
EISSN:
1364-5463
ISSN:
0300-922X
URN:
uuid:4e675b2c-247f-48d6-8ff9-fc130d52a80c
Source identifiers:
400267
Local pid:
pubs:400267
Language:
English

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