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Immunization with Porphyromonas gingivalis enolase induces autoimmunity to mammalian α-enolase and arthritis in DR4-IE-transgenic mice.

Abstract:

OBJECTIVE: To examine the hypothesis that the subset of rheumatoid arthritis (RA) characterized by antibodies to citrullinated α-enolase is mediated by Porphyromonas gingivalis enolase in the context of DR4 alleles. METHODS: Recombinant human α-enolase and P gingivalis enolase, either citrullinated or uncitrullinated, were used to immunize DR4-IE-transgenic mice and control mice (class II major histocompatibility complex-deficient [class II MHC(-/-)] and C57BL/6 wild-type mice). Arthritis wa...

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Publication status:
Published

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Publisher copy:
10.1002/art.30639

Authors


Kinloch, AJ More by this author
Alzabin, S More by this author
Brintnell, W More by this author
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Journal:
Arthritis and rheumatism
Volume:
63
Issue:
12
Pages:
3818-3823
Publication date:
2011-12-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:4e4b9929-38b0-49ba-a441-bb42154d321f
Source identifiers:
244868
Local pid:
pubs:244868

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