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Insights into the pre-initiation events of bacteriophage phi 6 RNA-dependent RNA polymerase: towards the assembly of a productive binary complex.

Abstract:

The RNA-dependent RNA polymerase (RdRP) of double-stranded RNA (dsRNA) viruses performs both RNA replication and transcription. In order to initiate RNA polymerization, viral RdRPs must be able to interact with the incoming 3' terminus of the template and position it, so that a productive binary complex is formed. Structural studies have revealed that RdRPs of dsRNA viruses that lack helicases have electrostatically charged areas on the polymerase surface, which might facilitate such interact...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gkn1035

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Journal:
Nucleic acids research
Volume:
37
Issue:
4
Pages:
1182-1192
Publication date:
2009-03-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:4e4a7c9f-c3b3-4145-8906-e64c052b2611
Source identifiers:
3047
Local pid:
pubs:3047

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