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Syncytiotrophoblast microvesicles released from pre-eclampsia placentae exhibit increased tissue factor activity.

Abstract:

BACKGROUND: Pre-eclampsia is a complication of pregnancy associated with activation of coagulation. It is caused by the placenta, which sheds increased amounts of syncytiotrophoblast microvesicles (STBM) into the maternal circulation. We hypothesized that STBM could contribute to the haemostatic activation observed in pre-eclampsia. METHODOLOGY/PRINCIPAL FINDINGS: STBM were collected by perfusion of the maternal side of placentae from healthy pregnant women and women with pre-eclampsia at ca...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0026313

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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
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Department of Health's National Institute for Health Research Biomedical Research Centres More from this funder
Oxford Partnership Comprehensive Biomedical Research Centre More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
6
Issue:
10
Pages:
Article: e26313
Publication date:
2011
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:4e44ebb9-02f6-4bc5-854c-451efcee9918
Source identifiers:
248276
Local pid:
pubs:248276

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