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Journal article

Pharmacokinetic and pharmacodynamic assessment of co-amoxiclav in the treatment of melioidosis.

Abstract:

OBJECTIVES: We conducted a prospective pharmacokinetic study of oral co-amoxiclav in patients with melioidosis to determine the optimal dosage and dosing interval in this potentially fatal infection. PATIENTS AND METHODS: Serial plasma concentrations were measured after administration of two 1 g tablets of Augmentin (1750 mg of amoxicillin and 250 mg of clavulanate) to 14 adult patients with melioidosis. Monte Carlo simulation was used to predict the concentration of each drug following mult...

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Publication status:
Published

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Publisher copy:
10.1093/jac/dkl389

Authors


Chierakul, W More by this author
Wangboonskul, J More by this author
Singtoroj, T More by this author
Pongtavornpinyo, W More by this author
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Journal:
The Journal of antimicrobial chemotherapy
Volume:
58
Issue:
6
Pages:
1215-1220
Publication date:
2006-12-05
DOI:
EISSN:
1460-2091
ISSN:
0305-7453
URN:
uuid:4e44d1dd-8293-47bc-9a77-87440d1f1a6a
Source identifiers:
15020
Local pid:
pubs:15020

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