Journal article icon

Journal article

Activation of CCR2+ human proinflammatory monocytes by human herpesvirus-6B chemokine N-terminal peptide.

Abstract:

Human monocytes expressing CCR2 with CD14 and CD16 can mediate antigen presentation, and promote inflammation, brain infiltration and immunosenescence. Recently identified roles are in human immunodeficiency virus infection, tuberculosis and parasitic disease. Human herpesvirus 6B (HHV-6B) encodes a chemokine, U83B, which is monospecific for CCR2, and is distinct from the related HHV-6A U83A, which activates CCR1, CCR4, CCR5, CCR6 and CCR8 on immune effector cells and dendritic cells. These d...

Expand abstract

Actions


Access Document


Publisher copy:
10.1099/vir.0.050153-0

Authors


Catusse, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Gompels, UA More by this author
Journal:
The Journal of general virology
Volume:
94
Issue:
Pt 7
Pages:
1624-1635
Publication date:
2013-07-05
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
URN:
uuid:4e393f7c-e391-4559-937c-df3944770e81
Source identifiers:
390837
Local pid:
pubs:390837

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP