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Downregulation of ASPP1 in gestational trophoblastic disease: Correlation with hypermethylation, apoptotic activity and clinical outcome

Abstract:

Gestational trophoblastic disease encompasses a spectrum of trophoblastic lesions including true neoplasms such as choriocarcinomas and the potentially malignant hydatidiform moles, which may develop persistent disease requiring chemotherapy. ASPP1, a member of apoptosis-stimulating proteins of p53 (ASPPs), is a proapoptotic protein that can stimulate apoptosis through its interaction with p53. We evaluated the promoter methylation and expression profiles of ASPP1 in different trophoblastic t...

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Publisher copy:
10.1038/modpathol.2010.216

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
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Journal:
Modern Pathology
Volume:
24
Issue:
4
Pages:
522-532
Publication date:
2011-04-05
DOI:
EISSN:
1530-0285
ISSN:
0893-3952
URN:
uuid:4e317187-5a04-4567-abdf-deafa4e4a7b5
Source identifiers:
139054
Local pid:
pubs:139054

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