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The nature of tremor circuits in parkinsonian and essential tremor

Abstract:

Tremor is a cardinal feature of Parkinson’s disease and essential tremor, the two most common movement disorders. Yet, the mechanisms underlying tremor generation remain largely unknown. We hypothesized that driving deep brain stimulation electrodes at a frequency closely matching the patient’s own tremor frequency should interact with neural activity responsible for tremor, and that the effect of stimulation on tremor should reveal the role of different deep ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/brain/awu250

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Subgroup:
BNDU
Role:
Author
ORCID:
0000-0002-1641-115X
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Role:
Author
ORCID:
0000-0001-6249-6230
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Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
137
Issue:
12
Pages:
3223-3234
Publication date:
2014-09-08
Acceptance date:
2014-07-23
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Pubs id:
pubs:483826
URN:
uri:4e29dbc8-4974-4745-8dec-3b6ae3a0db19
UUID:
uuid:4e29dbc8-4974-4745-8dec-3b6ae3a0db19
Local pid:
pubs:483826

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