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Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity.

Abstract:

The close correspondence between energy intake and expenditure over prolonged time periods, coupled with an apparent protection of the level of body adiposity in the face of perturbations of energy balance, has led to the idea that body fatness is regulated via mechanisms that control intake and energy expenditure. Two models have dominated the discussion of how this regulation might take place. The set point model is rooted in physiology, genetics and molecular biology, and suggests that the...

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Publication status:
Published

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Publisher copy:
10.1242/dmm.008698

Authors


Speakman, JR More by this author
Levitsky, DA More by this author
Allison, DB More by this author
de Castro, JM More by this author
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Journal:
Disease models and mechanisms
Volume:
4
Issue:
6
Pages:
733-745
Publication date:
2011-11-05
DOI:
EISSN:
1754-8411
ISSN:
1754-8403
URN:
uuid:4e228cd5-30f3-4ad4-adb3-274355b37955
Source identifiers:
417976
Local pid:
pubs:417976

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