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Genetic variation at the IL10 gene locus is associated with severity of respiratory syncytial virus bronchiolitis.

Abstract:

The intense airway inflammatory response associated with respiratory syncytial virus (RSV) infection may be an important determinant in the severity of the disease. Interleukin (IL)-10 is a key regulatory cytokine known to be secreted during this infection. We investigated the role that IL-10 plays in RSV disease by studying the effects that variation in the IL10 gene has on the outcome of the disease. Eight single nucleotide polymorphisms (SNPs) spanning the IL10 gene were selected, and hapl...

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Publication status:
Published

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Publisher copy:
10.1086/429636

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Journal:
The Journal of infectious diseases
Volume:
191
Issue:
10
Pages:
1705-1709
Publication date:
2005-05-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:4e2218c6-520b-424f-afc0-456caefd372f
Source identifiers:
133587
Local pid:
pubs:133587

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