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Retinol Dehydrogenase-10 Regulates Pancreas Organogenesis and Endocrine Cell Differentiation via Paracrine Retinoic Acid Signaling.

Abstract:

Vitamin A-derived retinoic acid (RA) signals are critical for the development of several organs, including the pancreas. However, the tissue-specific control of RA synthesis in organ and cell lineage development has only poorly been addressed in vivo. Here, we show that retinol dehydrogenase-10 (Rdh10), a key enzyme in embryonic RA production, has important functions in pancreas organogenesis and endocrine cell differentiation. Rdh10 was expressed in the developing pancreas epithelium and sur...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1210/en.2016-1745

Authors


Climent, M More by this author
Strasser, J More by this author
Gouignard, N More by this author
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Swedish Research Council More from this funder
Novo Nordisk Foundation More from this funder
Swedish Diabetes Foundation More from this funder
Director Albert Påhlsson Foundation More from this funder
Wenner Gren Foundation More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Endocrinology Journal website
Volume:
157
Issue:
12
Pages:
4615-4631
Publication date:
2016-10-14
Acceptance date:
2016-10-10
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
Pubs id:
pubs:653459
URN:
uri:4e13cbcd-0fa9-4256-83f9-5d2e9c3b44df
UUID:
uuid:4e13cbcd-0fa9-4256-83f9-5d2e9c3b44df
Local pid:
pubs:653459
Language:
English
Keywords:

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