- Abstract:
-
PURPOSE: Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP-3) gene have previously been identified in patients with Sorsby's fundus dystrophy (SFD). We evaluated the ocular distribution of TIMP-3 and other extracellular constituents in SFD. METHODS: The eyes of an SFD donor with a confirmed TIMP-3 mutation were examined using histologic techniques demonstrating connective tissue, calcium, and lipid. Immunohistochemical analyses were performed using antibodies against TIMP-3, col...
Expand abstract - Journal:
- Investigative ophthalmology and visual science
- Volume:
- 41
- Issue:
- 3
- Pages:
- 898-902
- Publication date:
- 2000-03-05
- EISSN:
-
1552-5783
- ISSN:
-
0146-0404
- URN:
-
uuid:4e127ae6-98bd-42a4-8812-598641d0e2fd
- Source identifiers:
-
254172
- Local pid:
- pubs:254172
- Copyright date:
- 2000
Journal article
TIMP-3, collagen, and elastin immunohistochemistry and histopathology of Sorsby's fundus dystrophy.
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