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TIMP-3, collagen, and elastin immunohistochemistry and histopathology of Sorsby's fundus dystrophy.

Abstract:

PURPOSE: Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP-3) gene have previously been identified in patients with Sorsby's fundus dystrophy (SFD). We evaluated the ocular distribution of TIMP-3 and other extracellular constituents in SFD. METHODS: The eyes of an SFD donor with a confirmed TIMP-3 mutation were examined using histologic techniques demonstrating connective tissue, calcium, and lipid. Immunohistochemical analyses were performed using antibodies against TIMP-3, col...

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Authors


Alexander, RA More by this author
Luthert, PJ More by this author
Journal:
Investigative ophthalmology and visual science
Volume:
41
Issue:
3
Pages:
898-902
Publication date:
2000-03-05
EISSN:
1552-5783
ISSN:
0146-0404
URN:
uuid:4e127ae6-98bd-42a4-8812-598641d0e2fd
Source identifiers:
254172
Local pid:
pubs:254172

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