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WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy.

Abstract:

WD-repeat proteins are regulatory beta-propeller platforms that enable the assembly of multiprotein complexes. Here, we report the functional and bioinformatic analysis of human WD-repeat protein Interacting with PhosphoInosides (WIPI)-1alpha (WIPI49/Atg18), a member of a novel WD-repeat protein family with autophagic capacity in Saccharomyces cerevisiae and Caenorhabditis elegans, recently identified as phospholipid-binding effectors. Our phylogenetic analysis divides the WIPI protein family...

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Publisher copy:
10.1038/sj.onc.1208331

Authors


Proikas-Cezanne, T More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Frickey, T More by this author
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Journal:
Oncogene
Volume:
23
Issue:
58
Pages:
9314-9325
Publication date:
2004-12-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:4e0c26d3-d876-40b4-9c54-361e3e99f80c
Source identifiers:
428105
Local pid:
pubs:428105

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