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An alkyne hydroacylation route to highly substituted furans.

Abstract:
More rings for your rhodium: Rhodium-catalyzed intermolecular alkyne hydroacylations deliver γ-hydroxy-α,β-enones, which can be cyclized in situ to deliver di-and trisubstituted furans. Functionalization of the intermediates using Heck chemistry allows the formation of regioisomeric furans. The use of an alternative Rh I catalyst delivers 1,4-dicarbonyl compounds and hence pyrroles, thiophenes, and pyridazines, all from the same two starting materials. Copyright © 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
Publication status:
Published

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Publisher copy:
10.1002/anie.201105795

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Journal:
Angewandte Chemie (International ed. in English)
Volume:
50
Issue:
45
Pages:
10657-10660
Publication date:
2011-11-05
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:4e09eef6-3b31-4312-80e6-e0c9addf4a04
Source identifiers:
180419
Local pid:
pubs:180419

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