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Targeted binding of PEG-lipid modified polymer ultrasound contrast agents with tiered surface architecture.

Abstract:

In order for site-directed polymer ultrasound contrast agents (UCAs) to provide acoustic enhancement at disease sites to distinguish normal tissue from diseased tissue, the surface of these agents must be functionalized with mixtures of grafted polymers. Here a combination of longer liganded polyethylene glycol (PEG)-lipids and shorter unliganded PEG-lipids were introduced into the oil phase of a modified solvent evaporation double emulsion method for preparing UCAs. UCAs with different lengt...

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Publication status:
Published

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Publisher copy:
10.1002/bit.22678

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Journal:
Biotechnology and bioengineering
Volume:
106
Issue:
3
Pages:
501-506
Publication date:
2010-06-05
DOI:
EISSN:
1097-0290
ISSN:
0006-3592
URN:
uuid:4df587ac-3772-41d1-b883-54d1c70f2942
Source identifiers:
327705
Local pid:
pubs:327705

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