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Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction

Abstract:

Transcriptionally activated monocytes are recruited to the heart after acute myocardial infarction (AMI). After AMI in mice and humans, the number of extracellular vesicles (EVs) increased acutely. In humans, EV number correlated closely with the extent of myocardial injury. We hypothesized that EVs mediate splenic monocyte mobilization and program transcription following AMI. Some plasma EVs bear endothelial cell (EC) integrins, and both proinflammatory stimulation of ECs and AMI significant...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1172/jci.insight.93344

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
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National Institute for Health Research More from this funder
Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
JCI insight Journal website
Volume:
2
Issue:
17
Pages:
Article: e93344)
Publication date:
2017-09-07
Acceptance date:
2017-07-27
DOI:
ISSN:
2379-3708
Pubs id:
pubs:726244
URN:
uri:4deb9c7f-8ec6-423d-8e15-5a7fe5961493
UUID:
uuid:4deb9c7f-8ec6-423d-8e15-5a7fe5961493
Local pid:
pubs:726244

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