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Large-scale evidence that the cardiotoxicity of smoking is not significantly modified by the apolipoprotein E epsilon2/epsilon3/epsilon4 genotype.

Abstract:

Results from two small studies, involving a total of only 174 cases, have suggested that the increased risk of coronary heart disease conferred by cigarette smoking is substantially affected by genotype at the apolipoprotein E (APOE) epsilon2/epsilon3/epsilon4 polymorphism. We have established APOE genotypes in 4484 patients with acute myocardial infarction diagnosed before the age of 55 years for male and 65 years for female patients, and in 5757 controls with no history of cardiovascular di...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit, BHF Centre of Research Excellence
Role:
Author
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Journal:
Lancet
Volume:
361
Issue:
9355
Pages:
396-398
Publication date:
2003-02-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:4dde12ec-f3ac-4fa6-91c4-ec41c982ebe0
Source identifiers:
38534
Local pid:
pubs:38534

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