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A panel of cancer-testis genes exhibiting broad-spectrum expression in haematological malignancies

Abstract:

Cancer-testis (CT) antigens/genes show restricted expression in normal tissues but widespread expression in many tumour types. This, coupled with their ability to induce cytotoxic T-lymphocyte responses, makes them attractive vaccine candidates. Following our identification of PASD1, we have used RT-PCR to analyse the mRNA expression profile of a large panel of CT genes in cell lines derived from haematological malignancies, and have studied Sp17 protein expression in the same cell lines and ...

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Journal:
Cancer Immunity
Volume:
10
Pages:
1-12
Publication date:
2010-01-01
EISSN:
1424-9634
URN:
uuid:4dcb06ab-3eae-4ff2-96ab-2c8f3d42f962
Source identifiers:
246603
Local pid:
pubs:246603

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