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The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener.

Abstract:

ATP-sensitive K(+) (K(ATP)) channels are activated by a diverse group of compounds known as potassium channel openers (PCOs). Here, we report functional studies of the Kir6.2/SUR1 Selective PCO 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide (NNC 55-9216). We recorded cloned K(ATP) channel currents from inside-out patches excised from Xenopus laevis oocytes heterologously expressing Kir6.2/SUR1, Kir6.2/SUR2A, or Kir6.2/SUR2B, corresponding to the beta-cell, cardiac, and smoot...

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Publication status:
Published

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Publisher copy:
10.2337/diabetes.51.6.1896

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Journal:
Diabetes
Volume:
51
Issue:
6
Pages:
1896-1906
Publication date:
2002-06-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:4dc94bd9-3039-4c0c-9671-f9f493e5ce57
Source identifiers:
114536
Local pid:
pubs:114536

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