Journal article
The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener.
- Abstract:
-
ATP-sensitive K(+) (K(ATP)) channels are activated by a diverse group of compounds known as potassium channel openers (PCOs). Here, we report functional studies of the Kir6.2/SUR1 Selective PCO 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide (NNC 55-9216). We recorded cloned K(ATP) channel currents from inside-out patches excised from Xenopus laevis oocytes heterologously expressing Kir6.2/SUR1, Kir6.2/SUR2A, or Kir6.2/SUR2B, corresponding to the beta-cell, cardiac, and smoot...
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- Publication status:
- Published
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- Publisher copy:
- 10.2337/diabetes.51.6.1896
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Authors
Bibliographic Details
- Journal:
- Diabetes
- Volume:
- 51
- Issue:
- 6
- Pages:
- 1896-1906
- Publication date:
- 2002-06-01
- DOI:
- EISSN:
-
1939-327X
- ISSN:
-
0012-1797
- Source identifiers:
-
114536
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:114536
- UUID:
-
uuid:4dc94bd9-3039-4c0c-9671-f9f493e5ce57
- Local pid:
- pubs:114536
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2002
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