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What makes a good case-control study? Design issues for complex traits such as endometriosis.

Abstract:

The combined investigation of environmental and genetic risk-factors in complex traits will refocus attention on the case-control study. Endometriosis is an example of a complex trait for which most case-control studies have not followed the basic criteria of epidemiological study design. Appropriate control selection has been a particular problem. This article reviews the principles underlying the design of case-control studies, and their application to the study of endometriosis. Only if it...

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Publication status:
Published

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Publisher copy:
10.1093/humrep/17.6.1415

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Cardon, LR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology, Biomedical Research Centre
Journal:
Human reproduction (Oxford, England)
Volume:
17
Issue:
6
Pages:
1415-1423
Publication date:
2002-06-05
DOI:
EISSN:
1460-2350
ISSN:
0268-1161
URN:
uuid:4dc5b836-ab75-4861-a40e-b03487661087
Source identifiers:
32121
Local pid:
pubs:32121

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