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A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups.

Abstract:

BACKGROUND: Adolescent idiopathic scoliosis (AIS) is a common rotational deformity of the spine that presents in children worldwide, yet its etiology is poorly understood. Recent genome-wide association studies (GWAS) have identified a few candidate risk loci. One locus near the chromosome 10q24.31 LBX1 gene (OMIM #604255) was originally identified by a GWAS of Japanese subjects and replicated in additional Asian populations. To extend this result, and to create larger AIS cohorts for the pur...

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Journal:
Journal of medical genetics
Volume:
51
Issue:
6
Pages:
401-406
Publication date:
2014-06-01
DOI:
EISSN:
1468-6244
ISSN:
0022-2593
Source identifiers:
462986
Language:
English
Keywords:
Pubs id:
pubs:462986
UUID:
uuid:4db77c45-84e3-43b4-ae19-923ee6b1a4cf
Local pid:
pubs:462986
Deposit date:
2014-05-20

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