Journal article icon

Journal article

Sixty years of placebo-controlled antipsychotic drug trials in acute schizophrenia: Systematic review, Bayesian meta-analysis, and meta-regression of efficacy predictors.

Abstract:

Objective

Antipsychotic drug efficacy may have decreased over the decades. We, therefore, present a comprehensive meta-analysis of all placebo-controlled trials in acute schizophrenia, we investigate which trial characteristics have changed over the years and which ones are moderators of drug-placebo efficacy differences.

Method

We searched multiple electronic databases, ClinicalTrials.gov and the FDA website. The outcomes were overall efficacy (primary outcome), ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

Actions


Access Document


Files:
Publisher copy:
10.1176/appi.ajp.2017.16121358

Authors


Chaimani, A More by this author
Mavridis, D More by this author
Expand authors...
Publisher:
American Psychiatric Association Publisher's website
Journal:
American Journal of Psychiatry Journal website
Volume:
174
Issue:
10
Pages:
927-942
Publication date:
2017-05-25
Acceptance date:
2017-03-20
DOI:
EISSN:
1535-7228
ISSN:
0002-953X
Pubs id:
pubs:698116
URN:
uri:4d95a9fd-233b-4b46-a327-f6458dfcb557
UUID:
uuid:4d95a9fd-233b-4b46-a327-f6458dfcb557
Local pid:
pubs:698116
Language:
English
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP