- Abstract:
-
Objective
Antipsychotic drug efficacy may have decreased over the decades. We, therefore, present a comprehensive meta-analysis of all placebo-controlled trials in acute schizophrenia, we investigate which trial characteristics have changed over the years and which ones are moderators of drug-placebo efficacy differences.
Method
We searched multiple electronic databases, ClinicalTrials.gov and the FDA website. The outcomes were overall efficacy (primary outcome), ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(pdf, 419.8kb)
-
- Publisher copy:
- 10.1176/appi.ajp.2017.16121358
-
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- Publisher:
- American Psychiatric Association Publisher's website
- Journal:
- American Journal of Psychiatry Journal website
- Volume:
- 174
- Issue:
- 10
- Pages:
- 927-942
- Publication date:
- 2017-05-25
- Acceptance date:
- 2017-03-20
- DOI:
- EISSN:
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1535-7228
- ISSN:
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0002-953X
- Pubs id:
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pubs:698116
- URN:
-
uri:4d95a9fd-233b-4b46-a327-f6458dfcb557
- UUID:
-
uuid:4d95a9fd-233b-4b46-a327-f6458dfcb557
- Local pid:
- pubs:698116
- Language:
- English
- Keywords:
- Copyright holder:
- American Psychiatric Association
- Copyright date:
- 2017
- Notes:
- © 2017 American Psychiatric Association. This is the accepted manuscript version of the article. The final version is available online from American Psychiatric Association at: http://dx.doi.org/10.1176/appi.ajp.2017.16121358
- License:
- CC BY-NC-ND
Journal article
Sixty years of placebo-controlled antipsychotic drug trials in acute schizophrenia: Systematic review, Bayesian meta-analysis, and meta-regression of efficacy predictors.
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