Sixty years of placebo-controlled antipsychotic drug trials in acute schizophrenia: Systematic review, Bayesian meta-analysis, and meta-regression of efficacy predictors.
Antipsychotic drug efficacy may have decreased over the decades. We, therefore, present a comprehensive meta-analysis of all placebo-controlled trials in acute schizophrenia, we investigate which trial characteristics have changed over the years and which ones are moderators of drug-placebo efficacy differences.
We searched multiple electronic databases, ClinicalTrials.gov and the FDA website. The outcomes were overall efficacy (primary outcome), ...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Accepted manuscript, pdf, 419.8KB)
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- Copyright holder:
- American Psychiatric Association
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- © 2017 American Psychiatric Association. This is the accepted manuscript version of the article. The final version is available online from American Psychiatric Association at: http://dx.doi.org/10.1176/appi.ajp.2017.16121358
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